I tried this earlier tonight, had the same problem alot of people have reported at first, my bobber would go out, the mouse would go over it, but no click. After changing the profile from the SW day to one of my own for the night, and pushing my graphics settings back up from where I'd lowered them, I solved it.
Also for people who are fishing whilst in the room, but watching TV/Reading/Generally doing other things, I've added the 'Whisper Enhanced' addon, which should show up if its googled for.
This should be handy incase any suspicious GMs whisper you.
It keeps whispers up on your screen instead of fading in the chat box, as well as making a sound when you receive a whisper. I personally replaced the default sound with the bunny troubles wav from the first link when googling for 'alarm wav'
"You've got troubles Mac!"
Apologies for not linking, as my post count isn't yet high enough.