Yep. In GhomConstants.au3, CTRL+F for "LootFrame". I use 1920x1080, so I've adjusted mine as follows:
Code:
__AddPixelToArray("LootFrame", "", "600,120,1392,862", "194,10,1358,866", "115,124,946,696", "", "146,7,1126,553")
For each aspect ratio, the first number is the leftmost X coordinate, the second is the top Y coordinate, the third is the rightmost X coordinate, and the fourth is the bottom Y coordinate. Adjust to shrink where it looks for loot. For me, I changed it so it wouldnt get my companions green text and also wouldnt click on legendaries/sets linked in chat.
GLHF