I can run 10 man fine (Sometimes gets laggy when stacking up or moving a lot, but still playable. You can notice a difference when the profile is enabled and when it isn't to say it best). It's when I use the profile and run lfr or a world boss where it becomes utterly impossible to use because of how laggy it becomes, and it's definitely the profile as as soon as it's disabled, I go up by 30 FPS and into an actual playable state. The same LUA error is appearing when you mouseover or target yourself with the profile enabled. Version 2.1.01, I play at 30 latency.
I have better specs then listed above by the way(Why would you ever play with such a high PQR delay by the way? I use any other profile at 20ms and no problems - only limited yourself at that point, frame drops have to be coming from somewhere or a combination of multiple things).
Good examples are lfr iron qon and oondasta, during the final phase of iron qon the profile ends up being so laggy (8 Fps, down from the usual 40 at that point of time), Oondasta it drops to 5 FPS or bellow, of the average 30-40 FPS I get there (high pop server).