Well, first off it would be helpful to know why you can't edit the DB manually, a query would require us to know your db creature_proto table's structure and it would be very hard to do this through only a query, if you were using a 3.3.5 db i could help you a bit more, but if you can run like
Code:
SELECT * FROM `creature_proto` WHERE `id` = ***ENTER BOSS NPC ID HERE***;
this plus the table structure would allow us to write you a query,
alternatively you could use an update command like this, but once again table structure would be helpful.
Code:
UPDATE `creature_proto`
SET `minhealth`=5000000, `max_health`=5000000, `mindamage`=75000, `maxdamage`=100000
WHERE `id`=***BOSS NPC ID HERE***;