These are all area wide quests, just run into the zone and quests will start popping up.
There is a Rakghoul Vaccine purchasable from the stim vendor in Outpost Zaroshe. I had an uncleansable disease called "Feverish", I later exploded and died.
3 World Bosses, Outlaw's Den and Sarlacc are the locations of two of them
There are 5 Codex Entries followed by a Title upon completion