You might want to take a look on google scholar for some academic papers on this question. Just a simple search can be seen:
Here
I reasonable paper mentions the type of detection (behavioral) that honorbuddy users have been suggesting happened a bit ago:
Here
While there are these methods available, I bet most here would agree that not a lot of companies employ the more "intrusive" methods for risk of false positives. However, you do see a higher proliferation in anticheat techniques since gaming is quite a popular market (Look at all the anti-cheat systems out there).