With a decently geared barb you can solo ghom on inferno easy.
1. Charge with life steal (dreadnaught)
2. Overpower with reflect
3. Ignore Pain with reflect
4. Beserker Insanity
L. Frenzy with sidearm
R. War cry with resistances
Begin by dpsing, Ghom will cast clouds on you.
When this occurs and you're low health or half, cast overpower or ignore pain and charge to get a full heal. I like to use overpower then charge, then while both are on cd, use ignore pain. My barb has high res and vit so it works great for me even with the small 15k dps i can do..